Efficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer

PURPOSE: Trop-2, expressed in most triple-negative breast cancers (TNBCs), may be a potential target for antibody-drug conjugates. Sacituzumab govitecan, an antibody-drug conjugate, targets Trop-2 for the selective delivery of SN-38, the active metabolite of irinotecan. PATIENTS AND METHODS: We eval...

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Udgivet i:J Clin Oncol
Main Authors: Bardia, Aditya, Mayer, Ingrid A., Diamond, Jennifer R., Moroose, Rebecca L., Isakoff, Steven J., Starodub, Alexander N., Shah, Nikita C., O’Shaughnessy, Joyce, Kalinsky, Kevin, Guarino, Michael, Abramson, Vandana, Juric, Dejan, Tolaney, Sara M., Berlin, Jordan, Messersmith, Wells A., Ocean, Allyson J., Wegener, William A., Maliakal, Pius, Sharkey, Robert M., Govindan, Serengulam V., Goldenberg, David M., Vahdat, Linda T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2017
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ORIGINAL REPORTS
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559902/
https://ncbi.nlm.nih.gov/pubmed/28291390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2016.70.8297
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