Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation

Interleukin 23 (IL-23) regulates the development of TH17 cells, which are important for antimicrobial and antifungal responses and autoimmune and chronic inflammatory diseases. IL-23-induced Jak/STAT signaling is mediated via the heterodimeric IL-23 receptor (IL-23R)–IL-12 receptor β1 (IL-12Rβ1) com...

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Bibliografski detalji
Izdano u:Mol Cell Biol
Glavni autori: Hummel, Thorben M., Ackfeld, Theresa, Schönberg, Marco, Ciupka, Gregor, Schulz, Falk, Oberdoerster, Anne, Grötzinger, Joachim, Scheller, Jürgen, Floss, Doreen M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559674/
https://ncbi.nlm.nih.gov/pubmed/28630278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00014-17
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