A PHOSPHOSITE WITHIN THE SH2 DOMAIN OF LCK REGULATES ITS ACTIVATION BY CD45

The Src Family kinase Lck sets a critical threshold for T cell activation because it phosphorylates the TCR complex and the Zap70 kinase. How a T cell controls the abundance of active Lck molecules remains poorly understood. We have identified an unappreciated role for a phosphosite, Y192, within th...

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Udgivet i:Mol Cell
Main Authors: Courtney, Adam H., Amacher, Jeanine F., Kadlecek, Theresa A., Mollenauer, Marianne N., Au-Yeung, Byron B., Kuriyan, John, Weiss, Arthur
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558854/
https://ncbi.nlm.nih.gov/pubmed/28735895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.06.024
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