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Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice
PURPOSE: Cx46fs380 mice model a human autosomal-dominant cataract caused by a mutant lens connexin46, Cx46. Lenses from Cx46fs380 mice develop cataracts that are first observed at ∼2 months in homozygotes and at ≥4 months in heterozygotes. The present studies were conducted to determine whether Cx46...
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| Pubblicato in: | Invest Ophthalmol Vis Sci |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Association for Research in Vision and Ophthalmology
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5558631/ https://ncbi.nlm.nih.gov/pubmed/28810266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-21684 |
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