Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice

PURPOSE: Cx46fs380 mice model a human autosomal-dominant cataract caused by a mutant lens connexin46, Cx46. Lenses from Cx46fs380 mice develop cataracts that are first observed at ∼2 months in homozygotes and at ≥4 months in heterozygotes. The present studies were conducted to determine whether Cx46...

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Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Minogue, Peter J., Gao, Junyuan, Zoltoski, Rebecca K., Novak, Layne A., Mathias, Richard T., Beyer, Eric C., Berthoud, Viviana M.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2017
Fag:
Lens
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558631/
https://ncbi.nlm.nih.gov/pubmed/28810266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-21684
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