DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice

TREX1/DNASE III, the most abundant 3′-5′ DNA exonuclease in mammalian cells, is tail-anchored on the endoplasmic reticulum (ER). Mutations at the N-terminus affecting TREX1 DNase activity are associated with autoimmune and inflammatory conditions such as Aicardi-Goutières syndrome (AGS). Mutations i...

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Publicado no:J Autoimmun
Main Authors: Sakai, Tomomi, Miyazaki, Takuya, Shin, Dong-Mi, Kim, Yong-Soo, Qi, Chen-Feng, Fariss, Robert, Munasinghe, Jeeva, Wang, Hongsheng, Kovalchuk, Alexander L., Kothari, Parul H., Fermaintt, Charles S., Atkinson, John P., Perrino, Fred W., Yan, Nan, Morse, Herbert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558601/
https://ncbi.nlm.nih.gov/pubmed/28325644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2017.03.001
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