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BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing

Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain. However, compared with the expression and function of bioactive mature domain, the biological role of the pro-domain is poorly understood. Unexpectedly, we found that the pro-d...

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Veröffentlicht in:Neural Regen Res
Hauptverfasser: Mizui, Toshiyuki, Ohira, Koji, Kojima, Masami
Format: Artigo
Sprache:Inglês
Veröffentlicht: Medknow Publications & Media Pvt Ltd 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558473/
https://ncbi.nlm.nih.gov/pubmed/28852376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1673-5374.211173
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