BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met

Most growth factors are initially synthesized as precursor proteins and subsequently processed into their mature form by proteolytic cleavage, resulting in simultaneous removal of a pro-peptide. However, compared with that of mature form, the biological role of the pro-peptide is poorly understood....

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Mizui, Toshiyuki, Ishikawa, Yasuyuki, Kumanogoh, Haruko, Lume, Maria, Matsumoto, Tomoya, Hara, Tomoko, Yamawaki, Shigeto, Takahashi, Masami, Shiosaka, Sadao, Itami, Chiaki, Uegaki, Koichi, Saarma, Mart, Kojima, Masami
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466729/
https://ncbi.nlm.nih.gov/pubmed/26015580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422336112
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