BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met

Most growth factors are initially synthesized as precursor proteins and subsequently processed into their mature form by proteolytic cleavage, resulting in simultaneous removal of a pro-peptide. However, compared with that of mature form, the biological role of the pro-peptide is poorly understood....

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Mizui, Toshiyuki, Ishikawa, Yasuyuki, Kumanogoh, Haruko, Lume, Maria, Matsumoto, Tomoya, Hara, Tomoko, Yamawaki, Shigeto, Takahashi, Masami, Shiosaka, Sadao, Itami, Chiaki, Uegaki, Koichi, Saarma, Mart, Kojima, Masami
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466729/
https://ncbi.nlm.nih.gov/pubmed/26015580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422336112
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