BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met

Most growth factors are initially synthesized as precursor proteins and subsequently processed into their mature form by proteolytic cleavage, resulting in simultaneous removal of a pro-peptide. However, compared with that of mature form, the biological role of the pro-peptide is poorly understood....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mizui, Toshiyuki, Ishikawa, Yasuyuki, Kumanogoh, Haruko, Lume, Maria, Matsumoto, Tomoya, Hara, Tomoko, Yamawaki, Shigeto, Takahashi, Masami, Shiosaka, Sadao, Itami, Chiaki, Uegaki, Koichi, Saarma, Mart, Kojima, Masami
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466729/
https://ncbi.nlm.nih.gov/pubmed/26015580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422336112
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