Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium

The intracellular scaffold KRIT1/CCM1 is an established regulator of vascular barrier function. Loss of KRIT1 leads to decreased microvessel barrier function and to the development of the vascular disorder Cerebral Cavernous Malformation (CCM). However, how loss of KRIT1 causes the subsequent defici...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Goitre, Luca, DiStefano, Peter V., Moglia, Andrea, Nobiletti, Nicholas, Baldini, Eva, Trabalzini, Lorenza, Keubel, Julie, Trapani, Eliana, Shuvaev, Vladimir V., Muzykantov, Vladimir R., Sarelius, Ingrid H., Retta, Saverio Francesco, Glading, Angela J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558000/
https://ncbi.nlm.nih.gov/pubmed/28811547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08373-4
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