Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo

Oxidant stress caused by pathological elevation of reactive oxygen species (ROS) production in the endothelial cells lining the vascular lumen is an important component of many vascular and pulmonary disease conditions. NADPH oxidase (NOX) activated by pathological mediators including angiotensin an...

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Autori principali: Hood, Elizabeth D., Greineder, Colin F., Dodia, Chandra, Han, Jingyan, Mesaros, Clementina, Shuvaev, Vladimir V., Blair, Ian A., Fisher, Aron B., Muzykantov, Vladimir R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495982/
https://ncbi.nlm.nih.gov/pubmed/22974832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.08.031
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