KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun

Loss-of-function mutations in the KRIT1 gene (CCM1) have been associated with the pathogenesis of cerebral cavernous malformations (CCM), a major cerebrovascular disease. However, KRIT1 functions and CCM pathogenetic mechanisms remain incompletely understood. Indeed, recent experiments in animal mod...

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Detalhes bibliográficos
Main Authors: Goitre, Luca, De Luca, Elisa, Braggion, Stefano, Trapani, Eliana, Guglielmotto, Michela, Biasi, Fiorella, Forni, Marco, Moglia, Andrea, Trabalzini, Lorenza, Retta, Saverio Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2014
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Original Contributions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994518/
https://ncbi.nlm.nih.gov/pubmed/24291398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.11.020
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