RGD delivery of truncated coagulase to tumor vasculature affords local thrombotic activity to induce infarction of tumors in mice

Induction of thrombosis in tumor vasculature represents an appealing strategy for combating cancer. Herein, we combined unique intrinsic coagulation properties of staphylocoagulase with new acquired functional potentials introduced by genetic engineering, to generate a novel bi-functional fusion pro...

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Vydáno v:Sci Rep
Hlavní autoři: Jahanban-Esfahlan, Rana, Seidi, Khaled, Monhemi, Hassan, Adli, Amir Daei Farshchi, Minofar, Babak, Zare, Peyman, Farajzadeh, Davoud, Farajnia, Safar, Behzadi, Ramezan, Abbasi, Mehran Mesgari, Zarghami, Nosratollah, Javaheri, Tahereh
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557930/
https://ncbi.nlm.nih.gov/pubmed/28811469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05326-9
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