RGD delivery of truncated coagulase to tumor vasculature affords local thrombotic activity to induce infarction of tumors in mice

Induction of thrombosis in tumor vasculature represents an appealing strategy for combating cancer. Herein, we combined unique intrinsic coagulation properties of staphylocoagulase with new acquired functional potentials introduced by genetic engineering, to generate a novel bi-functional fusion pro...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jahanban-Esfahlan, Rana, Seidi, Khaled, Monhemi, Hassan, Adli, Amir Daei Farshchi, Minofar, Babak, Zare, Peyman, Farajzadeh, Davoud, Farajnia, Safar, Behzadi, Ramezan, Abbasi, Mehran Mesgari, Zarghami, Nosratollah, Javaheri, Tahereh
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557930/
https://ncbi.nlm.nih.gov/pubmed/28811469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05326-9
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