The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation

Mycobacterium tuberculosis PtpA is a secreted effector protein that dephosphorylates several proteins in the host cell cytoplasm, such as p-JNK, p-p38, and p-VPS33B, leading to suppression of host innate immunity. Here we show that, in addition, PtpA enters the nucleus of host cells and regulates th...

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Pubblicato in:Nat Commun
Autori principali: Wang, Jing, Ge, Pupu, Qiang, Lihua, Tian, Feng, Zhao, Dongdong, Chai, Qiyao, Zhu, Mingzhao, Zhou, Rongbin, Meng, Guangxun, Iwakura, Yoichiro, Gao, George Fu, Liu, Cui Hua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557760/
https://ncbi.nlm.nih.gov/pubmed/28811474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00279-z
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