Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H(+)–ATPase to inhibit phagosome acidification

Mycobacterium tuberculosis (Mtb) pathogenicity depends on its ability to inhibit phagosome acidification and maturation processes after engulfment by macrophages. Here, we show that the secreted Mtb protein tyrosine phosphatase (PtpA) binds to subunit H of the macrophage vacuolar-H(+)-ATPase (V-ATPa...

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Bibliographic Details
Main Authors: Wong, Dennis, Bach, Horacio, Sun, Jim, Hmama, Zakaria, Av-Gay, Yossef
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228452/
https://ncbi.nlm.nih.gov/pubmed/22087003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109201108
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