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Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H(+)–ATPase to inhibit phagosome acidification
Mycobacterium tuberculosis (Mtb) pathogenicity depends on its ability to inhibit phagosome acidification and maturation processes after engulfment by macrophages. Here, we show that the secreted Mtb protein tyrosine phosphatase (PtpA) binds to subunit H of the macrophage vacuolar-H(+)-ATPase (V-ATPa...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3228452/ https://ncbi.nlm.nih.gov/pubmed/22087003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109201108 |
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