Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H(+)–ATPase to inhibit phagosome acidification

Mycobacterium tuberculosis (Mtb) pathogenicity depends on its ability to inhibit phagosome acidification and maturation processes after engulfment by macrophages. Here, we show that the secreted Mtb protein tyrosine phosphatase (PtpA) binds to subunit H of the macrophage vacuolar-H(+)-ATPase (V-ATPa...

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Detalles Bibliográficos
Autores principales: Wong, Dennis, Bach, Horacio, Sun, Jim, Hmama, Zakaria, Av-Gay, Yossef
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228452/
https://ncbi.nlm.nih.gov/pubmed/22087003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109201108
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