Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H(+)–ATPase to inhibit phagosome acidification

Mycobacterium tuberculosis (Mtb) pathogenicity depends on its ability to inhibit phagosome acidification and maturation processes after engulfment by macrophages. Here, we show that the secreted Mtb protein tyrosine phosphatase (PtpA) binds to subunit H of the macrophage vacuolar-H(+)-ATPase (V-ATPa...

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Autors principals: Wong, Dennis, Bach, Horacio, Sun, Jim, Hmama, Zakaria, Av-Gay, Yossef
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228452/
https://ncbi.nlm.nih.gov/pubmed/22087003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109201108
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