Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H(+)–ATPase to inhibit phagosome acidification

Mycobacterium tuberculosis (Mtb) pathogenicity depends on its ability to inhibit phagosome acidification and maturation processes after engulfment by macrophages. Here, we show that the secreted Mtb protein tyrosine phosphatase (PtpA) binds to subunit H of the macrophage vacuolar-H(+)-ATPase (V-ATPa...

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Hlavní autoři: Wong, Dennis, Bach, Horacio, Sun, Jim, Hmama, Zakaria, Av-Gay, Yossef
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228452/
https://ncbi.nlm.nih.gov/pubmed/22087003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109201108
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