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Transcriptional and epigenetic regulation of T cell hyporesponsiveness

Naive CD8(+) T cells differentiate into effector and memory cytolytic T cells (CTLs) during an acute infection. In contrast, in scenarios of persistent antigen stimulation, such as chronic infections and cancer, antigen-specific CTLs show a gradual decrease in effector function, a phenomenon that ha...

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Bibliografiske detaljer
Udgivet i:J Leukoc Biol
Main Authors: Pereira, Renata M., Hogan, Patrick G., Rao, Anjana, Martinez, Gustavo J.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Leukocyte Biology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557644/
https://ncbi.nlm.nih.gov/pubmed/28606939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.2RI0317-097R
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