Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism is not understood. Here we show underlying molecular mechanism using EAE mice. Under stress conditions, EAE caused severe gastrointestinal failure with high-mortality. Mechanistically, autoreactive...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Arima, Yasunobu, Ohki, Takuto, Nishikawa, Naoki, Higuchi, Kotaro, Ota, Mitsutoshi, Tanaka, Yuki, Nio-Kobayashi, Junko, Elfeky, Mohamed, Sakai, Ryota, Mori, Yuki, Kawamoto, Tadafumi, Stofkova, Andrea, Sakashita, Yukihiro, Morimoto, Yuji, Kuwatani, Masaki, Iwanaga, Toshihiko, Yoshioka, Yoshichika, Sakamoto, Naoya, Yoshimura, Akihiko, Takiguchi, Mitsuyoshi, Sakoda, Saburo, Prinz, Marco, Kamimura, Daisuke, Murakami, Masaaki
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557598/
https://ncbi.nlm.nih.gov/pubmed/28809157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25517
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