A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

Although pain is a common symptom of various diseases and disorders, its contribution to disease pathogenesis is not well understood. Here we show using murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), that pain induces EAE relapse. Mechanistic analysis sh...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Arima, Yasunobu, Kamimura, Daisuke, Atsumi, Toru, Harada, Masaya, Kawamoto, Tadafumi, Nishikawa, Naoki, Stofkova, Andrea, Ohki, Takuto, Higuchi, Kotaro, Morimoto, Yuji, Wieghofer, Peter, Okada, Yuka, Mori, Yuki, Sakoda, Saburo, Saika, Shizuya, Yoshioka, Yoshichika, Komuro, Issei, Yamashita, Toshihide, Hirano, Toshio, Prinz, Marco, Murakami, Masaaki
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530187/
https://ncbi.nlm.nih.gov/pubmed/26193120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08733
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