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The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats

The strong reinforcing effects of nicotine and the negative symptoms such as anxiety experienced during a quit attempt often lead to relapse and low success rates for smoking cessation. Treatments that not only block the reinforcing effects of nicotine but also attenuate the motivation to relapse ar...

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Detalhes bibliográficos
Publicado no:Behav Brain Res
Main Authors: Yuan, Menglu, Malagon, Ariana M., Yasuda, Dennis, Belluzzi, James D., Leslie, Frances M., Zaveri, Nurulain T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557392/
https://ncbi.nlm.nih.gov/pubmed/28693859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2017.07.004
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