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Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible. Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficiency of combinatorial genetic...
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| Pubblicato in: | Nat Biotechnol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5557292/ https://ncbi.nlm.nih.gov/pubmed/28319085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3834 |
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