The Tetrameric Plant Lectin BanLec Neutralizes HIV through Bidentate Binding to Specific Viral Glycans

Select lectins have powerful anti-viral properties that effectively neutralize HIV-1 by targeting the dense glycan shield on the virus. Here, we reveal the mechanism by which one of the most potent lectins, BanLec, achieves its inhibition. We identify that BanLec recognizes a subset of high-mannose...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Hopper, Jonathan T.S., Ambrose, Stephen, Grant, Oliver C., Krumm, Stefanie A., Allison, Timothy M., Degiacomi, Matteo T., Tully, Mark D., Pritchard, Laura K., Ozorowski, Gabriel, Ward, Andrew B., Crispin, Max, Doores, Katie J., Woods, Robert J., Benesch, Justin L.P., Robinson, Carol V., Struwe, Weston B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556678/
https://ncbi.nlm.nih.gov/pubmed/28434916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.03.015
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