Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis

BACKGROUND: Chemotherapy-induced premature ovarian failure (POF) is a severe complication affecting tumor patients at a childbearing age. Mesenchymal stem cells (MSCs) can partially restore the ovarian structure and function damaged by chemotherapy. miR-21 is a microRNA that can regulate cell apopto...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Fu, Xiafei, He, Yuanli, Wang, Xuefeng, Peng, Dongxian, Chen, Xiaoying, Li, Xinran, Wang, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556338/
https://ncbi.nlm.nih.gov/pubmed/28807003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-017-0641-z
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