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A general empirical model for renal drug handling in pharmacokinetic analyses
Dose adjustment in renal insufficiency is generally based on the assumption that renal drug clearance is related linearly to glomerular filtration rate. The theory underpinning this model is the intact nephron hypothesis, which says that impaired renal function is caused by a reduction in the number...
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| Publié dans: | Br J Clin Pharmacol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5555866/ https://ncbi.nlm.nih.gov/pubmed/28419522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13306 |
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