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A general empirical model for renal drug handling in pharmacokinetic analyses
Dose adjustment in renal insufficiency is generally based on the assumption that renal drug clearance is related linearly to glomerular filtration rate. The theory underpinning this model is the intact nephron hypothesis, which says that impaired renal function is caused by a reduction in the number...
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| Veröffentlicht in: | Br J Clin Pharmacol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5555866/ https://ncbi.nlm.nih.gov/pubmed/28419522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13306 |
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