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A general empirical model for renal drug handling in pharmacokinetic analyses

Dose adjustment in renal insufficiency is generally based on the assumption that renal drug clearance is related linearly to glomerular filtration rate. The theory underpinning this model is the intact nephron hypothesis, which says that impaired renal function is caused by a reduction in the number...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Wright, Daniel F. B., Duffull, Stephen B.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555866/
https://ncbi.nlm.nih.gov/pubmed/28419522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13306
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