Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression

Expression quantitative trait locus (eQTL) detection has emerged as an important tool for unraveling of the relationship between genetic risk factors and disease or clinical phenotypes. Most studies use single marker linear regression to discover primary signals, followed by sequential conditional m...

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Veröffentlicht in:G3 (Bethesda)
Hauptverfasser: Zeng, Biao, Lloyd-Jones, Luke R., Holloway, Alexander, Marigorta, Urko M., Metspalu, Andres, Montgomery, Grant W., Esko, Tonu, Brigham, Kenneth L., Quyyumi, Arshed A., Idaghdour, Youssef, Yang, Jian, Visscher, Peter M., Powell, Joseph E., Gibson, Greg
Format: Artigo
Sprache:Inglês
Veröffentlicht: Genetics Society of America 2017
Schlagworte:
Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555460/
https://ncbi.nlm.nih.gov/pubmed/28600440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.117.043752
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