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A Genetic Screen Reveals an Unexpected Role for Yorkie Signaling in JAK/STAT-Dependent Hematopoietic Malignancies in Drosophila melanogaster
A gain-of-function mutation in the tyrosine kinase JAK2 (JAK2(V617F)) causes human myeloproliferative neoplasms (MPNs). These patients present with high numbers of myeloid lineage cells and have numerous complications. Since current MPN therapies are not curative, there is a need to find new regulat...
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| Publicat a: | G3 (Bethesda) |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Genetics Society of America
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5555452/ https://ncbi.nlm.nih.gov/pubmed/28620086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.117.044172 |
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