Lack of MTTP protein in pluripotent stem cell-derived hepatocytes/cardiomyocytes abolishes apoB secretion and increases cell stress

Abetalipoproteinemia (ABL) is an inherited disorder of lipoprotein metabolism resulting from mutations in Microsomal Triglyceride Transfer Protein (MTTP). In addition to the liver and intestine, MTTP is expressed in cardiomyocytes and cardiomyopathy has been reported in several ABL cases. Using indu...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Liu, Ying, Conlon, Donna M., Bi, Xin, Slovik, Katherine J., Shi, Jianting, Edelstein, Hailey I., Millar, John S., Javaheri, Ali, Cuchel, Marina, Pashos, Evanthia E., Iqbal, Jahangir, Hussain, M. Mahmood, Hegele, Robert A., Yang, Wenli, Duncan, Stephen A., Rader, Daniel J., Morrisey, Edward E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555078/
https://ncbi.nlm.nih.gov/pubmed/28514664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.04.064
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