ANGPTL3 Inhibition With Evinacumab Results in Faster Clearance of IDL and LDL apoB in Patients With Homozygous Familial Hypercholesterolemia—Brief Report

OBJECTIVE: The mechanism by which evinacumab, a fully human monoclonal antibody directed against ANGPTL3 (angiopoietin-like 3 protein) lowers plasma LDL (low-density lipoprotein) cholesterol levels in patients with homozygous familial hypercholesterolemia is unknown. We investigated apoB (apolipopro...

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Опубликовано в: :Arterioscler Thromb Vasc Biol
Главные авторы: Reeskamp, Laurens F., Millar, John S., Wu, Liya, Jansen, Hans, van Harskamp, Dewi, Schierbeek, Henk, Gipe, Daniel A., Rader, Daniel J., Dallinga-Thie, Geesje M., Hovingh, G. Kees, Cuchel, Marina
Формат: Artigo
Язык:Inglês
Опубликовано: Lippincott Williams & Wilkins 2021
Предметы:
Translational Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8057526/
https://ncbi.nlm.nih.gov/pubmed/33691480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315204
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