Differential DNA methylation in familial hypercholesterolemia

Background: Familial hypercholesterolemia (FH) is a monogenic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C). A FH causing genetic variant in LDLR, APOB, or PCSK9 is not identified in 12–60% of clinical FH patients (FH mutation-negative patients). We aimed to assess w...

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Detalhes bibliográficos
Main Authors: Laurens F. Reeskamp, Andrea Venema, Joao P.Belo Pereira, Evgeni Levin, Max Nieuwdorp, Albert K. Groen, Joep C. Defesche, Aldo Grefhorst, Peter Henneman, G.Kees Hovingh
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-11-01
Colecção:EBioMedicine
Assuntos:
Familial hypercholesterolemia
LDLR
DNA methylation
Epigenetics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2352396420304552
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