Colonic tumorigenesis in BubR1(+/–)Apc(Min/+) compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability

Faithful chromosome segregation is essential for the maintenance of genetic stability during cell division and it is at least partly monitored by the spindle checkpoint, a surveillance mechanism preventing the cell from prematurely entering anaphase. The adenomatous polyposis coli (Apc) gene also pl...

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Detalhes bibliográficos
Main Authors: Rao, Chinthalapally V., Yang, Yang-Ming, Swamy, Malisetty V., Liu, Tongyi, Fang, Yuqiang, Mahmood, Radma, Jhanwar-Uniyal, Meena, Dai, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC555497/
https://ncbi.nlm.nih.gov/pubmed/15767571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407822102
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