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Colonic tumorigenesis in BubR1(+/–)Apc(Min/+) compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
Faithful chromosome segregation is essential for the maintenance of genetic stability during cell division and it is at least partly monitored by the spindle checkpoint, a surveillance mechanism preventing the cell from prematurely entering anaphase. The adenomatous polyposis coli (Apc) gene also pl...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC555497/ https://ncbi.nlm.nih.gov/pubmed/15767571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407822102 |
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