Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses

High-throughput screening allows rapid identification of new candidate compounds for biological probe or drug development. Here, we describe a principled method to generate “assay performance profiles” for individual compounds that can serve as a basis for similarity searches and cluster analyses. O...

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Bibliografske podrobnosti
izdano v:J Biomol Screen
Main Authors: Dančík, Vlado, Carrel, Hyman, Bodycombe, Nicole E., Seiler, Kathleen Petri, Fomina-Yadlin, Dina, Kubicek, Stefan T., Hartwell, Kimberly, Shamji, Alykhan F., Wagner, Bridget K., Clemons, Paul A.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554958/
https://ncbi.nlm.nih.gov/pubmed/24464433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057113520226
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