Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group

[Image: see text] The oxetane ring serves as an isostere of the carbonyl moiety, suggesting that oxetan-3-ol may be considered as a potential surrogate of the carboxylic acid functional group. To investigate this structural unit, as well as thietan-3-ol and the corresponding sulfoxide and sulfone de...

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Lassalas, Pierrik, Oukoloff, Killian, Makani, Vishruti, James, Michael, Tran, Van, Yao, Yuemang, Huang, Longchuan, Vijayendran, Krishna, Monti, Ludovica, Trojanowski, John Q., Lee, Virginia M.-Y., Kozlowski, Marisa C., Smith, Amos B., Brunden, Kurt R., Ballatore, Carlo
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2017
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554911/
https://ncbi.nlm.nih.gov/pubmed/28835803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00212
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