Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity

[Image: see text] Naturally derived chemical compounds are the foundation of much of our pharmacopeia, especially in antiproliferative and anti-infective drug classes. Here, we report that a naturally derived molecule called carmaphycin B is a potent inhibitor against both the asexual and sexual blo...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: LaMonte, Gregory M., Almaliti, Jehad, Bibo-Verdugo, Betsaida, Keller, Lena, Zou, Bing Yu, Yang, Jennifer, Antonova-Koch, Yevgeniya, Orjuela-Sanchez, Pamela, Boyle, Colleen A., Vigil, Edgar, Wang, Lawrence, Goldgof, Gregory M., Gerwick, Lena, O’Donoghue, Anthony J., Winzeler, Elizabeth A., Gerwick, William H., Ottilie, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554889/
https://ncbi.nlm.nih.gov/pubmed/28696697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00671
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