Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice

3-(3-Morpholinopropyl)-7,8-dihydro-6H-indeno[5,6-e][1,2,4]triazine 1,4-dioxide (SN30- 000), an analog of the well-studied bioreductive prodrug tirapazamine (TPZ), has improved activity against hypoxic cells in tumor xenografts. However, little is known about its biotransformation in normal tissues....

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Publicat a:Front Pharmacol
Autors principals: Gu, Yongchuan, Chang, Tony T.-A., Wang, Jingli, Jaiswal, Jagdish K., Edwards, David, Downes, Noel J., Liyanage, H. D. Sarath, Lynch, Courtney R. H., Pruijn, Frederik B., Hickey, Anthony J. R., Hay, Michael P., Wilson, William R., Hicks, Kevin O.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554537/
https://ncbi.nlm.nih.gov/pubmed/28848445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00531
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