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G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning
Biased agonism at G protein coupled receptors emerges as an opportunity for development of drugs with enhanced benefit/risk balance making biased ligand identification a priority. However, ligand biased signature, classically inferred from ligand activity across multiple pathways, displays high vari...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5554226/ https://ncbi.nlm.nih.gov/pubmed/28801617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07392-5 |
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