OVEREXPRESSING WILD-TYPE γ2 SUBUNITS RESCUED THE SEIZURE PHENOTYPE IN GABRG2(+/Q390X) DRAVET SYNDROME MICE

OBJECTIVE: The mutant γ-aminobutyric acid type A (GABA(A)) receptor γ2(Q390X) subunit, (Q351X in the mature peptide) has been associated with the epileptic encephalopathy, Dravet syndrome, and the epilepsy syndrome genetic epilepsy with febrile seizures plus (GEFS+). The mutation generates a prematu...

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Detalhes bibliográficos
Publicado no:Epilepsia
Main Authors: Huang, Xuan, Zhou, Chengwen, Tian, Mengnan, Kang, Jing-Qiong, Shen, Wangzhen, Verdier, Kelienne, Pimenta, Aurea, Macdonald, Robert L
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554098/
https://ncbi.nlm.nih.gov/pubmed/28586508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.13810
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