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PPARα Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil
Gemfibrozil, a peroxisome proliferator-activated receptor α (PPARα) agonist, is widely used for hypertriglyceridemia and mixed hyperlipidemia. Drug-drug interaction of gemfibrozil and other PPARα agonists has been reported. But the role of PPARα in Cytochrome P450 (CYP) induction by fibrates is not...
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| Publicado no: | Basic Clin Pharmacol Toxicol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5554081/ https://ncbi.nlm.nih.gov/pubmed/28374976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcpt.12794 |
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