Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder

BACKGROUND: Major depressive disorder (MDD) is the second largest cause of global disease burden. It has an estimated heritability of 37%, but published genome-wide association studies have so far identified few risk loci. Haplotype-block-based regional heritability mapping (HRHM) estimates the loca...

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Detalhes bibliográficos
Publicado no:Biol Psychiatry
Main Authors: Zeng, Yanni, Navarro, Pau, Shirali, Masoud, Howard, David M., Adams, Mark J., Hall, Lynsey S., Clarke, Toni-Kim, Thomson, Pippa A., Smith, Blair H., Murray, Alison, Padmanabhan, Sandosh, Hayward, Caroline, Boutin, Thibaud, MacIntyre, Donald J., Lewis, Cathryn M., Wray, Naomi R., Mehta, Divya, Penninx, Brenda W.J.H., Milaneschi, Yuri, Baune, Bernhard T., Air, Tracy, Hottenga, Jouke-Jan, Mbarek, Hamdi, Castelao, Enrique, Pistis, Giorgio, Schulze, Thomas G., Streit, Fabian, Forstner, Andreas J., Byrne, Enda M., Martin, Nicholas G., Breen, Gerome, Müller-Myhsok, Bertram, Lucae, Susanne, Kloiber, Stefan, Domenici, Enrico, Deary, Ian J., Porteous, David J., Haley, Chris S., McIntosh, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Priority Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553996/
https://ncbi.nlm.nih.gov/pubmed/28153336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2016.12.012
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