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Effect of polygenic risk scores on depression in childhood trauma

Background Research on gene × environment interaction in major depressive disorder (MDD) has thus far primarily focused on candidate genes, although genetic effects are known to be polygenic. Aims To test whether the effect of polygenic risk scores on MDD is moderated by childhood trauma. Method The...

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Main Authors: Peyrot, Wouter J., Milaneschi, Yuri, Abdellaoui, Abdel, Sullivan, Patrick F., Hottenga, Jouke J., Boomsma, Dorret I., Penninx, Brenda W. J. H.
Format: Artigo
Jezik:Inglês
Izdano: Royal College of Psychiatrists 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118052/
https://ncbi.nlm.nih.gov/pubmed/24925986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1192/bjp.bp.113.143081
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