Furoates and Thenoates Inhibit Pyruvate Dehydrogenase Kinase 2 Allosterically by Binding to its Pyruvate Regulatory Site

The last decade has witnessed the reawakening of cancer metabolism as a therapeutic target. In particular, inhibition of pyruvate dehydrogenase kinase (PDK) holds remarkable promise. Dichloroacetic acid (DCA), currently undergoing clinical trials, is a unique PDK inhibitor in which it binds to the a...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Masini, Tiziana, Birkaya, Barbara, van Dijk, Simon, Mondal, Milon, Hekelaar, Johan, Jäger, Manuel, Terwisscha van Scheltinga, Anke C., Patel, Mulchand S., Hirsch, Anna K. H., Moman, Edelmiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553292/
https://ncbi.nlm.nih.gov/pubmed/27435185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1201812
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