Plasticity and Epitope Exposure of the HIV-1 Envelope Trimer

We recently showed that mutations in the HIV-1 envelope (Env) destabilize the V3 loop, rendering neutralization-resistant viruses sensitive to V3-directed monoclonal antibodies (MAbs). Here, we investigated the propagation of this effect on other Env epitopes, with special emphasis on V2 loop exposu...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Powell, Rebecca L. R., Totrov, Maxim, Itri, Vincenza, Liu, Xiaomei, Fox, Alisa, Zolla-Pazner, Susan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Structure and Assembly
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553165/
https://ncbi.nlm.nih.gov/pubmed/28615206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00410-17
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