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Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses

The V1V2 region of the HIV-1 envelope is the target of several broadly neutralizing antibodies (bNAbs). Antibodies to V1V2 elicited in the RV144 clinical trial correlated with a reduced risk of HIV infection, but these antibodies were without broad neutralizing activity. Antibodies targeting V1V2 al...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:	Cell Rep
Κύριοι συγγραφείς:	Hessell, Ann J., Powell, Rebecca, Jiang, Xunqing, Luo, Christina, Weiss, Svenja, Dussupt, Vincent, Itri, Vincenza, Fox, Alisa, Shapiro, Mariya B., Pandey, Shilpi, Cheever, Tracy, Fuller, Deborah H., Park, Byung, Krebs, Shelly J., Totrov, Maxim, Haigwood, Nancy L., Kong, Xiang-Peng, Zolla-Pazner, Susan
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	2019
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6666430/ https://ncbi.nlm.nih.gov/pubmed/31340151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.074
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Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses

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