Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses

The V1V2 region of the HIV-1 envelope is the target of several broadly neutralizing antibodies (bNAbs). Antibodies to V1V2 elicited in the RV144 clinical trial correlated with a reduced risk of HIV infection, but these antibodies were without broad neutralizing activity. Antibodies targeting V1V2 al...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Hessell, Ann J., Powell, Rebecca, Jiang, Xunqing, Luo, Christina, Weiss, Svenja, Dussupt, Vincent, Itri, Vincenza, Fox, Alisa, Shapiro, Mariya B., Pandey, Shilpi, Cheever, Tracy, Fuller, Deborah H., Park, Byung, Krebs, Shelly J., Totrov, Maxim, Haigwood, Nancy L., Kong, Xiang-Peng, Zolla-Pazner, Susan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6666430/
https://ncbi.nlm.nih.gov/pubmed/31340151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.074
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