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The Utilization of a Unified Pharmacophore Query in the Discovery of New Antagonists of the Adenosine Receptor Family
Pharmacophore queries from previously known potent selective A(3) antagonists were generated by Chem-X. These queries were used to search a pharmacophore database of diverse compounds (CNS-Set™). In vitro assays of 186 ‘hits’ yielded over 30 active compounds, for four adenosine receptor subtypes. Th...
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| Yayımlandı: | Bioorg Med Chem Lett |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2000
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5553072/ https://ncbi.nlm.nih.gov/pubmed/10636237 |
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