NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology

Autosomal recessive polycystic kidney disease (ARPKD) is an important childhood nephropathy, occurring 1 in 20,000 live births. The major clinical phenotypes are expressed in the kidney with dilatation of the collecting ducts, systemic hypertension, and progressive renal insufficiency, and in the li...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kaimori, Jun-ya, Lin, Cheng-Chao, Outeda, Patricia, Garcia-Gonzalez, Miguel A., Menezes, Luis F., Hartung, Erum A., Li, Ao, Wu, Guanqing, Fujita, Hideaki, Sato, Yasunori, Nakanuma, Yasuni, Yamamoto, Satoko, Ichimaru, Naotsugu, Takahara, Shiro, Isaka, Yoshitaka, Watnick, Terry, Onuchic, Luiz F., Guay-Woodford, Lisa M., Germino, Gregory G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552802/
https://ncbi.nlm.nih.gov/pubmed/28798345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08284-4
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados