CYP2C19*2 and CYP2C19*17 variants and effect of tamoxifen on breast cancer recurrence: Analysis of the International Tamoxifen Pharmacogenomics Consortium dataset

The role of cytochrome P450 drug metabolizing enzymes in the efficacy of tamoxifen treatment of breast cancer is subject to substantial interest and controversy. CYP2D6 have been intensively studied, but the role of CYP2C19 is less elucidated, and we studied the association of CYPC19 genotype and re...

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Publicado no:Sci Rep
Main Authors: Damkier, Per, Kjærsgaard, Anders, Barker, Kimberly A., Cronin-Fenton, Deidre, Crawford, Anatasha, Hellberg, Ylva, Janssen, Emilius A. M., Langefeld, Carl, Ahern, Thomas P., Lash, Timothy L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552748/
https://ncbi.nlm.nih.gov/pubmed/28798474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08091-x
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