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Abl Kinase Regulation by BRAF/ERK and Cooperation with Akt in Melanoma
The melanoma incidence continues to increase, and the disease remains incurable for many due to its metastatic nature and high rate of therapeutic resistance. In particular, melanomas harboring BRAF(V600E) and PTEN mutations often are resistant to current therapies, including BRAF inhibitors (BRAFi)...
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| Udgivet i: | Oncogene |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5552414/ https://ncbi.nlm.nih.gov/pubmed/28368422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.76 |
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